Vertical bone regeneration using rhBMP-2 and VEGF
Identifieur interne : 000011 ( Main/Exploration ); précédent : 000010; suivant : 000012Vertical bone regeneration using rhBMP-2 and VEGF
Auteurs : Lara Schorn [Allemagne] ; Christoph Sproll [Allemagne] ; Michelle Ommerborn [Allemagne] ; Christian Naujoks [Allemagne] ; Norbert R. Kübler [Allemagne] ; Rita Depprich [Allemagne]Source :
- Head & Face Medicine [ 1746-160X ] ; 2017.
Abstract
Sufficient vertical and lateral bone supply and a competent osteogenic healing process are prerequisities for the successful osseointegration of dental implants in the alveolar bone. Several techniques including autologous bone grafts and guided bone regeneration are applied to improve quality and quantity of bone at the implantation site. Depending on the amount of lacking bone one- or two-stage procedures are required. Vertical bone augmentation has proven to be a challenge particularly in terms of bone volume stability. This study focuses on the three dimensional vertical bone generation in a one stage procedure in vivo. Therefore, a collagenous disc-shaped scaffold (ICBM = Insoluble Collagenous Bone Matrix) containing rhBMP-2 (Bone Morphogenetic Protein-2) and/or VEGF (Vascular Endothelial Growth Factor) was applied around the coronal part of a dental implant during insertion. RhBMP-2 and VEGF released directly at the implantation site were assumed to induce the generation of new vertical bone around the implant.
One hundred eight titanium implants were inserted into the mandible and the tibia of 12 mini pigs. Four experimental groups were formed: Control group, ICBM, ICBM + BMP-2, and ICBM + BMP-2 + VEGF.
After 1, 4 and 12 weeks the animals were sacrificed and bone generation was investigated histologically and histomorphometrically.
After 12 weeks the combination of ICBM + rhBMP2 + VEGF showed significantly more bone volume density (BVD%), a higher vertical bone gain (VBG) and more vertical bone gain around the implant (PVBG) in comparison to the control group.
By using collagenous disc-shaped matrices in combination with rhBMP-2 and VEGF vertical bone can be generated in a one stage procedure without donor site morbidity. The results of the presenting study suggest that the combination of rhBMP-2 and VEGF applied locally by using a collagenous carrier improves vertical bone generation in vivo. Further research is needed to establish whether this technique is applicable in clinical routines.
Url:
DOI: 10.1186/s13005-017-0146-0
PubMed: 28592312
PubMed Central: 5463342
Affiliations:
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last="Schorn">Lara Schorn</name><affiliation wicri:level="3"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2176 9917</institution-id><institution-id institution-id-type="GRID">grid.411327.2</institution-id><institution>Department of Oral-, Maxillo- and Plastic Facial Surgery,</institution><institution>Heinrich-Heine-University Duesseldorf,</institution></institution-wrap>Moorenstr. 5, 40225 Duesseldorf, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Moorenstr. 5, 40225 Duesseldorf</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Düsseldorf</region><settlement type="city">Düsseldorf</settlement></placeName></affiliation></author><author><name sortKey="Sproll, Christoph" sort="Sproll, Christoph" uniqKey="Sproll C" first="Christoph" last="Sproll">Christoph Sproll</name><affiliation wicri:level="3"><nlm:aff 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2176 9917</institution-id><institution-id institution-id-type="GRID">grid.411327.2</institution-id><institution>Department of Operative and Preventive Dentistry and Endodontics,</institution><institution>Heinrich-Heine-University Duesseldorf,</institution></institution-wrap>Moorenstr. 5, Duesseldorf, 40225 Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Moorenstr. 5, Duesseldorf</wicri:regionArea><wicri:noRegion>Duesseldorf</wicri:noRegion><wicri:noRegion>Duesseldorf</wicri:noRegion><wicri:noRegion>Duesseldorf</wicri:noRegion></affiliation></author><author><name sortKey="Naujoks, Christian" sort="Naujoks, Christian" uniqKey="Naujoks C" first="Christian" last="Naujoks">Christian Naujoks</name><affiliation wicri:level="3"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2176 9917</institution-id><institution-id institution-id-type="GRID">grid.411327.2</institution-id><institution>Department of Oral-, Maxillo- and Plastic Facial Surgery,</institution><institution>Heinrich-Heine-University Duesseldorf,</institution></institution-wrap>Moorenstr. 5, 40225 Duesseldorf, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Moorenstr. 5, 40225 Duesseldorf</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Düsseldorf</region><settlement type="city">Düsseldorf</settlement></placeName></affiliation></author><author><name sortKey="Kubler, Norbert R" sort="Kubler, Norbert R" uniqKey="Kubler N" first="Norbert R." last="Kübler">Norbert R. Kübler</name><affiliation wicri:level="3"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2176 9917</institution-id><institution-id institution-id-type="GRID">grid.411327.2</institution-id><institution>Department of Oral-, Maxillo- and Plastic Facial Surgery,</institution><institution>Heinrich-Heine-University Duesseldorf,</institution></institution-wrap>Moorenstr. 5, 40225 Duesseldorf, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Moorenstr. 5, 40225 Duesseldorf</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Düsseldorf</region><settlement type="city">Düsseldorf</settlement></placeName></affiliation></author><author><name sortKey="Depprich, Rita" sort="Depprich, Rita" uniqKey="Depprich R" first="Rita" last="Depprich">Rita Depprich</name><affiliation wicri:level="3"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2176 9917</institution-id><institution-id institution-id-type="GRID">grid.411327.2</institution-id><institution>Department of Oral-, Maxillo- and Plastic Facial Surgery,</institution><institution>Heinrich-Heine-University Duesseldorf,</institution></institution-wrap>Moorenstr. 5, 40225 Duesseldorf, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Moorenstr. 5, 40225 Duesseldorf</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Düsseldorf</region><settlement type="city">Düsseldorf</settlement></placeName></affiliation></author></analytic><series><title level="j">Head & Face Medicine</title><idno type="eISSN">1746-160X</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Sufficient vertical and lateral bone supply and a competent osteogenic healing process are prerequisities for the successful osseointegration of dental implants in the alveolar bone. Several techniques including autologous bone grafts and guided bone regeneration are applied to improve quality and quantity of bone at the implantation site. Depending on the amount of lacking bone one- or two-stage procedures are required. Vertical bone augmentation has proven to be a challenge particularly in terms of bone volume stability. This study focuses on the three dimensional vertical bone generation in a one stage procedure in vivo. Therefore, a collagenous disc-shaped scaffold (ICBM = Insoluble Collagenous Bone Matrix) containing rhBMP-2 (Bone Morphogenetic Protein-2) and/or VEGF (Vascular Endothelial Growth Factor) was applied around the coronal part of a dental implant during insertion. RhBMP-2 and VEGF released directly at the implantation site were assumed to induce the generation of new vertical bone around the implant.</p></sec><sec><title>Methods</title><p>One hundred eight titanium implants were inserted into the mandible and the tibia of 12 mini pigs. Four experimental groups were formed: Control group, ICBM, ICBM + BMP-2, and ICBM + BMP-2 + VEGF.</p><p>After 1, 4 and 12 weeks the animals were sacrificed and bone generation was investigated histologically and histomorphometrically.</p></sec><sec><title>Results</title><p>After 12 weeks the combination of ICBM + rhBMP2 + VEGF showed significantly more bone volume density (BVD%), a higher vertical bone gain (VBG) and more vertical bone gain around the implant (PVBG) in comparison to the control group.</p></sec><sec><title>Conclusion</title><p>By using collagenous disc-shaped matrices in combination with rhBMP-2 and VEGF vertical bone can be generated in a one stage procedure without donor site morbidity. The results of the presenting study suggest that the combination of rhBMP-2 and VEGF applied locally by using a collagenous carrier improves vertical bone generation in vivo. Further research is needed to establish whether this technique is applicable in clinical routines.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Cochran, Dl" uniqKey="Cochran D">DL Cochran</name></author><author><name sortKey="Schenk, R" uniqKey="Schenk R">R Schenk</name></author><author><name sortKey="Buser, D" uniqKey="Buser D">D Buser</name></author><author><name sortKey="Wozney, Jm" uniqKey="Wozney J">JM Wozney</name></author><author><name sortKey="Jones, Aa" uniqKey="Jones A">AA Jones</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jones, Aa" uniqKey="Jones A">AA Jones</name></author><author><name sortKey="Buser, D" uniqKey="Buser D">D Buser</name></author><author><name sortKey="Schenk, R" uniqKey="Schenk R">R Schenk</name></author><author><name sortKey="Wozney, J" uniqKey="Wozney J">J Wozney</name></author><author><name sortKey="Cochran, Dl" uniqKey="Cochran D">DL 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sortKey="Morgan, Ef" uniqKey="Morgan E">EF Morgan</name></author><author><name sortKey="Mortlock, Dp" uniqKey="Mortlock D">DP Mortlock</name></author><author><name sortKey="Einhorn, Ta" uniqKey="Einhorn T">TA Einhorn</name></author><author><name sortKey="Gerstenfeld, Lc" uniqKey="Gerstenfeld L">LC Gerstenfeld</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Refaat, M" uniqKey="Refaat M">M Refaat</name></author><author><name sortKey="Klineberg, Eo" uniqKey="Klineberg E">EO Klineberg</name></author><author><name sortKey="Fong, Mc" uniqKey="Fong M">MC Fong</name></author><author><name sortKey="Garcia, Tc" uniqKey="Garcia T">TC Garcia</name></author><author><name sortKey="Leach, Jk" uniqKey="Leach J">JK Leach</name></author><author><name sortKey="Haudenschild, Dr" uniqKey="Haudenschild D">DR Haudenschild</name></author></analytic></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>District de Düsseldorf</li><li>Rhénanie-du-Nord-Westphalie</li></region><settlement><li>Düsseldorf</li></settlement></list><tree><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Schorn, Lara" sort="Schorn, Lara" uniqKey="Schorn L" first="Lara" last="Schorn">Lara Schorn</name></region><name sortKey="Depprich, Rita" sort="Depprich, Rita" uniqKey="Depprich R" first="Rita" last="Depprich">Rita Depprich</name><name sortKey="Kubler, Norbert R" sort="Kubler, Norbert R" uniqKey="Kubler N" first="Norbert R." last="Kübler">Norbert R. Kübler</name><name sortKey="Naujoks, Christian" sort="Naujoks, Christian" uniqKey="Naujoks C" first="Christian" last="Naujoks">Christian Naujoks</name><name sortKey="Ommerborn, Michelle" sort="Ommerborn, Michelle" uniqKey="Ommerborn M" first="Michelle" last="Ommerborn">Michelle Ommerborn</name><name sortKey="Sproll, Christoph" sort="Sproll, Christoph" uniqKey="Sproll C" first="Christoph" last="Sproll">Christoph Sproll</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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